We study the neural circuit and molecular basis of individual differences in behavior using custom high-throughput instrumentation, with an eye to its ultimate cause in evolution.
The animal kingdom contains staggering morphological diversity, but even...
The long-term goal of the Brown laboratory is to understand the structure and function of cilia (also known as eukaryotic flagella).
Cilia are finger-like organelles that project from the surface of almost all eukaryotic cells. Motile cilia produce a...Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering.
Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems –...
Therapeutic Targeting of Protein-Protein Interactions. Protein-Protein Interactions (PPIs) are the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab...
Research in the Kruse Lab centers on molecular mechanisms of signal transduction by transmembrane receptors.
Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying...
The Loparo laboratory is focused on using biochemical and biophysical tools to study the mechanisms of genome maintenance with molecular resolution.
My laboratory is focused on developing and applying single-molecule methods to understand the dynamics...
Members of the Zhuang laboratory apply their diverse backgrounds in physics, chemistry, biology, and engineering to develop advanced imaging methods and to exploit these tools to study a variety of interesting biological problems. Understanding the...
We use both theory and experiments to study evolutionary dynamics and population genetics, particularly in situations where natural selection is pervasive.
Natural selection and other evolutionary forces lead to particular patterns of evolutionary...