George M. Church
Director of HMS NHGRI-Center of Excellence in Genomic Science, Director of Personal Genome Project
Broad Institute & Wyss Harvard Institute of Biologically Inspired Engineering
Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering.
Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems – in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses.
Dantas, G., Sommer, M.O., Oluwasegun, R.D., and Church, G.M. (2008) Bacteria Subsisting on Antibiotics. Science 320(5872):100-3.
Bang, D., and Church, G.M. (2008) Gene Synthesis by Circular Assembly Amplification. Nature Methods 5(1):37-9.
Kim, J.B., Porreca, G.J., Gorham, J.M., Church, G.M., Seidman, C.E., and Seidman, J.G. (2007) Polony Multiplex Analysis of Gene Expression (PMAGE) in a Mouse Model of Hypertrophic Cardiomyopathy. Science 316(5830):1481-4.
Bakal, C., Aach, J., Church, G.M., and Perrimon, N. (2007) Defining the Components Of Local Signaling Networks That Regulate Cell Morphology Using Quantitative Morphological Signatures. Science 316(5832):1753-6.
Profile Photograph Credit: Wyss Institute at Harvard University
Department of Genetics
Nee Research Building, Room 238
77 Avenue Louis Pasteur
Boston, MA 02115