My research seeks to uncover the principles that govern how neural circuits, both biological and artificial, represent and transform information.
A central focus of my group is the geometry of neural population activity, or “neural manifolds,” which...
In our lab, we focus on studying immune regulation through a biophysical lens. Our work is guided by fundamental principles of dynamical systems theory in reaction-diffusion systems.
This enables us to understand how different cell types interact and form...
Our lab focuses on the development of adaptive immune responses, protein evolution, and the
interactions between host and pathogen using a combination of biophysical, biochemical, and
molecular virology techniques.
We are primarily protein engineers and...
Our research group applies Positron Emission Tomography (PET), molecular imaging principles, and pharmacokinetic modeling methods to measure physiological parameters in vivo to better understand healthy brain function, aging, neuropsychiatric disorders...
We develop and apply single molecule approaches to acquire quantitative understanding of biology and to find ways to improve human medicine.
The current directions of our research include investigations of G-quadruplex and R-loop mediated gene...
Taekjip Ha analyzes single molecules to understand how they act in complex biological systems.
Ha and his team combine sophisticated biophysical manipulation techniques with fluorescence imaging to visualize and manipulate protein, RNA, and DNA molecules...
The Farnung Lab is interested in molecular mechanisms at the interface of transcription and chromatin.
We employ biochemical, biophysical, machine learning, and structural biology approaches to understand how the transcription machinery, histone...
My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis.
We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of...
My research program focuses on studying specialized translation mechanisms in parasites that significantly burden global health, including, but not limited to, Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing...
Our lab studies protein design and molecular recognition.
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens...