Dr. Taekjip Ha (He/ His)
Dept. of Pediatrics; Dept. of Biological Chemistry and Molecular Pharmacology
Boston Children's Hospital; Harvard Medical School
Taekjip Ha analyzes single molecules to understand how they act in complex biological systems.
Ha and his team combine sophisticated biophysical manipulation techniques with fluorescence imaging to visualize and manipulate protein, RNA, and DNA molecules. Probing these molecules allows the researchers to decipher such innate properties as a molecule’s “bendability” and how it binds and interacts with other molecules. Ha’s team strives to emulate or work within natural cellular environments while studying single molecules, testing diverse protein-nucleic acid and protein-protein interactions at unprecedented spatial and temporal resolution.
Selected Publications:
2. Y. Wang, W.T. Cottle, H. Wang, X.A. Feng, J. Mallon, M. Gavrilov, S. Bailey and T. Ha, “Genome Oligopaint via Local Denaturing Fluorescence In situ Hybridization”, Molecular Cell 81:1566-1577 (2021).
3. A. Basu, D.G. Bobrovnikov, Z. Qureshi, T. Kayikcioglu, T.T.M. Ngo, A. Ranjan, S. Eustermann, B. Cieza, M.T. Morgan, M. Hejna, H.T. Rube, K.P. Hopfner, C. Wolberger, J.S. Song and T. Ha, “Measuring DNA mechanics on the genome scale” Nature 589, 462-467 (2021).
4. R. S. Zou, A. Marin-Gonzalez, Y. Liu, H. B. Liu, L. Shen, R. Dveirin, J.X.J. Luo, R. Kalhor and T. Ha, “Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites” Nature Cell Biology 24, 1433-1444 (2022).
Contact Information
61 Binney Street, Boston
Boston Children's Hospital