We develop and apply single molecule approaches to acquire quantitative understanding of biology and to find ways to improve human medicine.
The current directions of our research include investigations of G-quadruplex and R-loop mediated gene...
Taekjip Ha analyzes single molecules to understand how they act in complex biological systems.
Ha and his team combine sophisticated biophysical manipulation techniques with fluorescence imaging to visualize and manipulate protein, RNA, and DNA molecules...
My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis.
We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of...
Projects in our lab focus on mechanotransduction or the conversion of mechanical signals into electrical signals in the inner ear. The process underlies our senses of hearing and balance. We have identified several proteins critical for...
Our lab studies the molecular mechanisms of sensory transduction, seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals. In particular, we focus on the sense of smell in...
The Prigozhin lab is involved in collaborative and interdisciplinary work in the area of single-cell and single-molecule biophysics of transmembrane signaling. We are particularly interested in cryo-vitrification, all kinds of electron and optical...
The Buratowski Lab studies eukaryotic gene transcription, chromatin regulation, and RNA processing using a wide range of biochemical, molecular, and genetic techniques.
The Buratowski lab studies eukaryotic gene expression, focusing on mRNA transcription...
Our proteome is shaped by transcription/translation, as much as by protein degradation. The latter, sometimes even leading to...
DNA replication and repair mechanisms that suppress genomic instability.
Xenopus laevis egg extracts have an extraordinary capacity to recapitulate key events of cell cycle progression in vitro, including DNA replication and repair, mitosis, and...