Single-Molecule Biophysics

We study receptor-ligand interactions and transmembrane signal transmission that are relevant to immunology, hemostasis, and human disease using structural, cell biological, and single molecule techniques.

We work on receptor-ligand interactions and...

Research in the Shih laboratory focuses on design of self-assembling biomolecular machines and their diagnostic and therapeutic applications.

Tools For Molecular Biophysics:

NMR Structure Determination of Membrane Proteins An outstanding problem in...

The Prentiss group focuses on using physics tools to elucidate important problems in biology.  The basic principles governing self-assembly have been a focus of recent work.

It has long been known that any complex self-assembling system faces a...

The Needleman laboratory investigates how the cooperative behaviors of molecules give rise to the architecture and dynamics of self-organizing subcellular structures.

These collective effects are not only directly relevant to cellular organization, they...

Our objective is to bridge the gap between molecules and cells, either as independent entities in culture, as components of organoids, or as components of living tissues.

Our research focuses on the processes that mediate and regulate the movement of...

Using in vivo dynamics of single molecules to dissect the mechanisms controlling bacterial shape and growth.

 

My group works to understand how cells create long range order: How enzymes, each acting at the nanometer scale, work together to build micron...

Molecular Principles Enabling Structural Diversification of Very Long-Chain Fatty Acids.  The budding yeast S. cerevisiae is a model organism in which the power of genetic screening and genomic analysis can be combined with biochemical reconstitution...

The Loparo laboratory is focused on using biochemical and biophysical tools to study the mechanisms of genome maintenance with molecular resolution.

My laboratory is focused on developing and applying single-molecule methods to understand the dynamics...

Members of the Zhuang laboratory apply their diverse backgrounds in physics,  chemistry, biology, and engineering to develop advanced imaging methods and to exploit these tools to study a variety of interesting biological problems.  Understanding the...

The Blacklow laboratory studies biochemical and molecular mechanisms of signal transduction. A major focus is on elucidating key events mediated by the Notch signaling pathway in health and disease.  

The primary long-term goal of our research program is...