Our lab studies microbial evolution, primarily of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance.
This will require advances both in technology and in the basic science of resistance evolution...
We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed at treating or preventing infection.
Several enveloped RNA viruses cause human viral hemorrhagic fevers...
DNA replication and repair mechanisms that suppress genomic instability.
Xenopus laevis egg extracts have an extraordinary capacity to recapitulate key events of cell cycle progression in vitro, including DNA replication and repair, mitosis, and...
We are a computational genetics and genomics lab whose main research is on genetic variation, including mechanisms of spontaneous mutagenesis, functional effects of mutations and allelic variants, population genetics and relationship between genotype and...
Research in the Shih laboratory focuses on design of self-assembling biomolecular machines and their diagnostic and therapeutic applications.
Tools For Molecular Biophysics:
NMR Structure Determination of Membrane Proteins An outstanding problem in...
Multiscale Theoretical and Experimental Studies of Physical Chemical Principles of Living Matter.
Mutations increase genetic diversity and affect molecular properties of proteins (stability, activity, solubility,etc.), while natural selection is the...
The main focus of my research laboratory is to understand the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.
In the first few years of life, humans tremendously expand their behavior...
To arrive at a decision, organisms must measure multiple environmental signals and interpret them appropriately. The questions we are interested in are how cells and organisms interpret...