Andrew C. Kruse
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Research in the Kruse Lab centers on molecular mechanisms of signal transduction by transmembrane receptors. Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying transmembrane signaling remain poorly understood. Our research aims to elucidate the molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and pharmacology. In particular, we are focused on the study of proteins important in human health and disease, including G protein-coupled receptors and other proteins that regulate neurotransmission and metabolic homeostasis. Major experimental techniques in the lab include combinatorial protein engineering, X-ray crystallography, lipidic mesophase crystallization, and receptor signaling and radioligand pharmacology.
Pascolutti RP, Sun X, Kao J, Maute R, Ring AM, Bowman GR, Kruse AC. Structure and dynamics of PD-L1 and an ultra high-affinity PD-1 receptor mutant. Structure. 2016 Oct 4;24(10):1719-1728.
Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC. Crystal structure of the human sigma-1 receptor.(2016) Nature 532, 527-530.
Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J. Muscarinic acetylcholine receptors: novel opportunities for drug development. (2014) Nat. Rev. Drug Discov., 13, 549-560.
Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. (2013) Nature 504, 101-106.
Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. (2012) Nature 482, 552-556.
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