In our lab, we focus on studying immune regulation through a biophysical lens. Our work is guided by fundamental principles of dynamical systems theory in reaction-diffusion systems.
This enables us to understand how different cell types interact and form...
Our lab focuses on the development of adaptive immune responses, protein evolution, and the
interactions between host and pathogen using a combination of biophysical, biochemical, and
molecular virology techniques.
We are primarily protein engineers and...
My laboratory is interested in the role of spatial organization in host-microbe interactions in the mammalian gut. We develop, extend, and utilize image-based approaches to spatial genomics, including a massively multiplexed single-molecule RNA imaging...
We develop and apply single molecule approaches to acquire quantitative understanding of biology and to find ways to improve human medicine.
The current directions of our research include investigations of G-quadruplex and R-loop mediated gene...
My research is focused on developing model systems to gain fundamental insights in disease mechanisms within the heart and the brain.
Using induced pluripotent stem cells (iPSCs) and genome editing, we create human disease models caused by ion channels...
The Farnung Lab is interested in molecular mechanisms at the interface of transcription and chromatin.
We employ biochemical, biophysical, machine learning, and structural biology approaches to understand how the transcription machinery, histone...
My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis.
We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of...
My research program focuses on studying specialized translation mechanisms in parasites that significantly burden global health, including, but not limited to, Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing...
Our lab seeks to enable the dissection of tissues into the rules which govern their organization.
Genomic tools for understanding tissue function are critically needed. Applying genomic technologies to tissues has faced three major challenges: first, to...
Our lab studies protein design and molecular recognition.
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens...