Our lab seeks to enable the dissection of tissues into the rules which govern their organization.

Genomic tools for understanding tissue function are critically needed. Applying genomic technologies to tissues has faced three major challenges: first, to parallelize many measurements at once to fully capture molecular complexity present; second, to expand measurements beyond just one modality; third, to straddle the wide length scales--nanometers to millimeters--at which tissue functions arise.  What has been critically missing is the ability to make scalable, highly multiplexed measurements that properly contextualize biomolecules in tissues across these disparate scales.

1. Measure: Scalable spatial genomic measurement technologies. How do we perform scalable and sensitive measurements of transcriptomes and genomic contexts?

2. Model: Computational models of cellular and molecular interaction networks. How do we nominate functional cellular and molecular interactions? 

3. Manipulate: Tissue genomic perturbation tools.  Causality requires functional perturbations. How do we manipulate interactions to mechanistically dissect tissue networks? 

Current Lab Members:

7 Graduate Students, 5 Postdocs