Single-Molecule Approaches

Stephen C. Blacklow, M.D., Ph.D.

Stephen C. Blacklow, M.D., Ph.D.

Gustavus Adolphus Pfeiffer Professor
Chair, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Member, Department of Cancer Biology, Dana Farber Cancer Institute

The Blacklow laboratory studies biochemical and molecular mechanisms of signal transduction. A major focus is on elucidating key events mediated by the Notch signaling pathway in health and disease.... Read more about Stephen C. Blacklow, M.D., Ph.D.

Harvard Medical School
LHRRB Building, Room 201B
45 Shattuck Street, Boston, MA 02115
p: 617 432-5176
SBuratowski Photo

Stephen Buratowski

Professor of Biological Chemistry and Moelcular Pharmacology
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Member, Harvard Center for Cancer Research

The Buratowski Lab studies eukaryotic gene transcription, chromatin regulation, and RNA processing using a wide range of biochemical, molecular, and genetic techniques.

... Read more about Stephen Buratowski
Building C1, Room 210
Harvard Medical School
240 Longwood Avenue
Boston, MA 02115
p: 617 432-0696
Luke Chao

Luke H. Chao

Assistant Professor
Department of Molecular Biology, Massachusetts General Hospital
Department of Genetics, Harvard Medical School
Organelle structure-function: We investigate how proteins self-organize in the birth, life and death of cellular compartments. Our goal is to understand how coupled, coordinated Ångstrom-scale motions propagate into micron-scale cellular rearrangements. ... Read more about Luke H. Chao
185 Cambridge Street, Simches Research Building, CPZN 6.808
Boston, MA 02114
p: (617) 724-2323
Michael Do

Michael T.H. Do

Associate Professor of Neurology, Harvard Medical School
F.M. Kirby Neurobiology Center, Boston Children's Hospital
Center for Brain Science, Harvard University; Division of Sleep Medicine, Brigham & Women's Hospital; Broad Institute, MIT & Harvard
Our lab asks how light drives functions that are as diverse as visual perception, sleep regulation, hormonal control, and setting of the internal body clock.... Read more about Michael T.H. Do
Center for Life Science 12061
3 Blackfan Circle
Boston, MA 02115
Sahand Hormoz

Sahand Hormoz

Assistant Professor
Department of Systems Biology, Harvard Medical School/ Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
Associate Member, Broad Institute of MIT and Harvard/ Affiliate Faculty, Harvard Stem Cell Institute
We use synthetic biology, single-molecule imaging, and single-cell analysis combined with mathematical modeling to understand the dynamics of cell state transitions in development and disease. ... Read more about Sahand Hormoz
360 Longwood Avenue
Longwood Center Building,
9th Floor, Room 310 (LC-9310)
Boston, MA 02115
p: 617 582-7361
Joseph Loparo

Joseph J. Loparo, Ph.D.

Associate Professor of Biological Chemistry and Molecular Pharmacology
Harvard Medical School

The Loparo laboratory is focused on developing and applying single-molecule methods to study genome maintenance.... Read more about Joseph J. Loparo, Ph.D.

Department of Biological Chemistry and Molecular Pharmacology
Seeley G. Mudd Building, Room 204B
240 Longwood Avenue
Boston, MA 02115
p: 617-432-5586
Alex K. Shalek

Alex K. Shalek

Pfizer-Laubach Career Development Associate Professor
Institute for Medical Engineering & Science and Department of Chemistry, MIT
Ragon Institute/ Broad Institute/ HMS/ MGH

Development and application of new technologies that facilitate understanding of how immune cells collectively perform systems-level functions in health and disease.... Read more about Alex K. Shalek

77 Massachusetts Avenue, Building E25, Room 348a
Massachusetts Institute of Technology
Cambridge, MA 02139
p: 617 324-5670
WesleyWongPhoto

Wesley P. Wong

Assistant Professor
Departments of Biological chemistry and Molecular Pharmacology and Pediatrics, Harvard Medical School
Program in Cellular and Molecular Medicine, Boston Children's Hospital
We investigate how force regulates the structure and dynamics of interactions between and within single-molecules, and how this in turn can affect the functioning and malfunctioning of biological systems.  ... Read more about Wesley P. Wong
Children's Hospital Boston, Wyss Institute for Biologically Inspired Engineering
3 Blackfan Circle, 3rd Floor
Boston, MA 02115
p: 617 713-8383
Hao Wu, Ph.D.

Hao Wu, Ph.D.

Asa and Patricia Springer Professor, Department of Biological Chemistry and Molecular Pharmacology
Department of Pediatrics, Harvard Medical School
Senior Investigator, Program in Cellular and Molecular Medicine, Boston Children’s Hospital

The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors.... Read more about Hao Wu, Ph.D.

Immune Disease Institute,
Center for Life Sciences Building
3 Blackfan Circle, 3rd Floor, Room 3099
Boston, MA 02115
p: 617 713-8160 f: 617 713-8161