Leonid A. Mirny, Ph.D.
Associate Member of the Broad Institute at Harvard and MIT; and of the Dana-Farber/Harvard Cancer Center
Institute for Medical Engineering and Science, MIT; and Harvard-MIT Division of Health Sciences and Technology
Using computational tools, modeling, and analysis of genomic data to address fundamental problems in biological physics and evolution.
Our laboratory research focuses on two major projects:
* Understanding 3D genome organization by computer modeling and analysis of different experimental data.
* Using cancer genomic data, computer simulations and comparative genomics to characterize cancer progression as an evolutionary process. Our goal is to use this knowledge to develop new therapeutic interventions.
Naumova N, Imakaev M, Fudenberg G, Zhan Y, Lajoie BR, Mirny LA, Dekker J. Organization of the Mitotic Chromosome. Science, 2013 342(6161).
Dekker J, Marti-Renom MA, Mirny LA. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nat Rev Genet. 2013 Jun;14(6):390-403.
Le TB, Imakaev MV, Mirny LA, Laub MT. High-resolution mapping of the spatial organization of a bacterial chromosome. Science. 2013 Nov 8;342(6159):731-4.
McFarland CD, Korolev KS, Kryukov GV, Sunyaev S, Mirny LA. The impact of deleterious passenger mutations on cancer progression. PNAS 2013 110(7).
Research highlight by Burgess DJ. "Tumor evolution Weighed down by passengers?" Nature Reviews Cancer (2013).
Christopher McFarland, Leonid Mirny, Kirill S. Korolev. A tug-of-war between driver and passenger mutations in cancer and other adaptive processes.
PNAS 2014 111(42):15138-43. http://www.ncbi.nlm.nih.gov/pubmed/25277973
complete list at
Building E25, Room 526
45 Carleton Street
Cambridge, MA 02139