Our research explores how we learn from our mistakes. As infants learning to walk, we take unsteady steps, fall, adjust, and eventually develop stable locomotion. This iterative cycle of action, error, and refinement continues throughout life, shaping our...
My laboratory is interested in the role of spatial organization in host-microbe interactions in the mammalian gut. We develop, extend, and utilize image-based approaches to spatial genomics, including a massively multiplexed single-molecule RNA imaging...
I lead an interdisciplinary research group with interests encompassing computational biology, imaging, and brain science. A core aim of our group is the development of computational methods for biomedical image analysis, with domains ranging from...
My research is focused on developing model systems to gain fundamental insights in disease mechanisms within the heart and the brain.
Using induced pluripotent stem cells (iPSCs) and genome editing, we create human disease models caused by ion channels...
Our research studies the molecular mechanisms of cellular fatty acid metabolism and lipid recycling pathways.
A long-term goal of my laboratory is to address mechanisms of cellular fatty acid metabolism and their implication in neuronal functions. Fatty...
Our lab seeks to enable the dissection of tissues into the rules which govern their organization.
Genomic tools for understanding tissue function are critically needed. Applying genomic technologies to tissues has faced three major challenges: first, to...
Projects in our lab focus on mechanotransduction or the conversion of mechanical signals into electrical signals in the inner ear. The process underlies our senses of hearing and balance. We have identified several proteins critical for...
Our DNA represents the full...
My lab works at the intersection of neurobiology, physics, and engineering. We combine functional and structural mapping of...
The focus of my career has been on advancing simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) toward meaningful clinical human use. Specifically, my efforts have concentrated on developing and validating this novel...