We are interested in understanding how complex motor sequences are learned and generated by the nervous system.
What is the identity of the neural circuits involved in motor learning and how do their respective functions change as the animal learns to...
We are interested in understanding how epigenetic chromatin domains are assembled and stably propagated.
Research in the Moazed lab is focused on the remarkable ability of heterochromatic domains of DNA to heritably silence genes and transposons. These...
DNA-TEMPLATED SMALL MOLECULES The discovery, synthesis, delivery and testing of small bioactive molecules remains an active focus of chemists in both...
Molecular Principles Enabling Structural Diversification of Very Long-Chain Fatty Acids. The budding yeast S. cerevisiae is a model organism in which the power of genetic screening and genomic analysis can be combined with biochemical reconstitution...
Researching Alzheimer's disease using multiphoton microscopy to observe, in vivo, the anatomy and physiology of specific cell type in the brain.Our laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease...
Understanding how the brain controls behavior by integrating external sensory information with internal states, such as attention or motivation.
In our lab in the Department of Neurobiology at Harvard Medical School, we worked for many years with non...
Statistical computations and neuronal mechanisms underlying complex decisions and behavior under uncertainty. The work in the lab is theoretical in nature, and we collaborate with experimentalists in a close loop to refine both theories and experiments...
Chromosome Mechanics and Dynamics
We are interested in complex chromosomal behaviors that lack satisfactory explanations. We emphasize new approaches, quantitative analysis and hypotheses that are orthogonal to general dogma. Current work combines...
Development and application of new technologies that facilitate understanding of how immune cells collectively perform systems-level functions in health and disease.
The interdisciplinary research in the Shalek Lab aims to create and implement new...
Bacterial toxin biology, therapeutics, and mechanism of membrane trafficking
Our laboratory has a broad interest in microbial toxins, bacterial pathogenesis in human/animal/insects, and microbiome. Along these lines of basic research, we are keen in...