Projects in our lab focus on mechanotransduction or the conversion of mechanical signals into electrical signals in the inner ear. The process underlies our senses of hearing and balance. We have identified several proteins critical for...
My lab designs new protein tools, artificial enzymes, and biomedicines to sense and re-direct cell signaling responses.
Molecular recognitions, such as receptor-ligand binding, enzyme-substrate recognition, or metabolite-protein interaction, are...
Our lab studies the molecular mechanisms of sensory transduction, seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals. In particular, we focus on the sense of smell in...
Our DNA represents the full...
The Prigozhin lab is involved in collaborative and interdisciplinary work in the area of single-cell and single-molecule biophysics of transmembrane signaling. We are particularly interested in cryo-vitrification, all kinds of electron and optical...
The Buratowski Lab studies eukaryotic gene transcription, chromatin regulation, and RNA processing using a wide range of biochemical, molecular, and genetic techniques.
The Buratowski lab studies eukaryotic gene expression, focusing on mRNA transcription...
The goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria (i.e., the microbiome) in order to uncover how these bacterial guests affect the human host.
We are not alone. The human body harbors more bacterial cells...
Our proteome is shaped by transcription/translation, as much as by protein degradation. The latter, sometimes even leading to...
Our lab studies microbial evolution, primarily of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance.
This will require advances both in technology and in the basic science of resistance evolution...