Pamela A. Silver

Pamela A. Silver

Elliot T. and Onie H. Adams Professor of Biochemistry and Systems Biology, Harvard Medical School
Pamela Silver Photo

The Silver Lab seeks to enhance our understanding of natural biological design, and to develop tools and concepts for designing cells, tissues and organisms. We develop synthetic cells that act as sensors, memory devices, bio-computers, producers of high value commodities and energy from the sun. We build novel subsystems such as protein controllers with designed properties for therapeutic use. 

We seek to both enhance our understanding of natural biological design, and to develop tools and concepts for designing cells, tissues and organisms. In the long term, we hope to develop principles for building synthetic cells that act as sensors, memory devices, bio-computers, producers of high value commodities and energy from the sun, and to build novel subsystems such as proteins with designed properties for therapeutic use. Current projects use mammalian cells, simple eukaryotes and prokaryotes. Understanding how to program cells in a rational way will have value, for example, in stem cell design, drug therapy and the environment. These experiments use a combination of theoretical and experimental approaches that are well suited to students with backgrounds in biology, engineering, or any allied field.

Selected Publications

Riglar, D.T., Giessen, T.W., Baym, M., Kerns, SJ., Niederhuber, MJ., Bronson, RT., Kotula, JW., Gerber, GK., Way, JC. and Silver, PA.* (2017) Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria, Nat. Biotechnol., Jul;35(7):653-65

Liu C, Colon BC, Ziesak M, Silver PA*, Nocera DG* (2016) Water-splitting biosynthetic system with CO2 reduction efficiencies exceeding photosynthesis. Science 352:1210-3. PMID: 27256881

Delebecque CJ, Lindner AB, Silver PA* and Aldaye FA (2011). Organization of intracellular reactions with rationally designed RNA assemblies. Science. 333:470-4. PMID: 21700839.

Burrill DR, Inniss MC, Boyle PM and Silver PA. (2012). Synthetic memory circuits for tracking human cell fate. Genes Dev. Jul 1;26(13):1486-97

Burrill DR, Vernet A, Collins JJ, Silver PA*, Way JC. (2016). Targeted erythropoietin selectively stimulates red blood cell expansion in vivo. Proc Natl Acad Sci. 113:5245-50. PMID:27114509

Contact Information

Warren Alpert Building, Room 420
200 Longwood Avenue, Boston, MA 02115

Assistant: Brianna Millor-Hammond
Email: Brianna_Millor-Hammond@hms.harvard.edu
Phone: 617 432-5041
p: 617 432-6401

Faculty Alphabetical