Research in the Shih laboratory focuses on design of self-assembling biomolecular machines and their diagnostic and therapeutic applications.
Tools For Molecular Biophysics:
NMR Structure Determination of Membrane Proteins An outstanding problem in...
Multiscale Theoretical and Experimental Studies of Physical Chemical Principles of Living Matter.
Mutations increase genetic diversity and affect molecular properties of proteins (stability, activity, solubility,etc.), while natural selection is the...
The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive...
The main focus of my research laboratory is to understand the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.
In the first few years of life, humans tremendously expand their behavior...
To arrive at a decision, organisms must measure multiple environmental signals and interpret them appropriately. The questions we are interested in are how cells and organisms interpret...
The Prentiss group focuses on using physics tools to elucidate important problems in biology. The basic principles governing self-assembly have been a focus of recent work.
It has long been known that any complex self-assembling system faces a...
Our laboratory is interested in how cell cycle signals regulate chromosome segregation and polarized morphogenesis. Our experimental approaches include a combination of biochemical, genetic and live-cell imaging.
My group studies cell division and...
We aim to understand the molecular mechanisms that determine the fate of new proteins using in vitro reconstitution, cell biology, and structural biology approaches. Protein biosynthesis is a complex process encompassing translation, protein folding...
The Rapoport lab studies how proteins move across membranes and how membranes are shaped.
We are interested in the molecular mechanisms by which proteins are transported across the endoplasmic reticulum (ER) membrane. Proteins are transported through a...
Assembling complex cytoskeletal architectures from simple building blocks.
For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial...