Department of Molecular Biology, Massachusetts General Hospital
Hans-Hermann Schoene Distinguished Investigator
microRNA and RNA interference mechanisms, neuroendocrine control of detoxification, immunity, metabolism, aging, and microbial diversity
Our lab uses C. elegans molecular genetics and genomics to study miRNA and RNAi pathways as well as mechanisms of aging and microbial surveillance. Using genetic and RNA interference approaches, we have identified genes that positively or negatively regulate RNAi and microRNA pathways. These genes reveal the trajectory of siRNAs and miRNAs as they target mRNAs, as well as components that may be developed as drug targets to enhance RNAi. This analysis has revealed subcellular organelles that mediate steps in the small RNA pathways.
Soukas, AA, CE Carr, and G Ruvkun. 2013. Genetic Regulation of C. elegans Lysosome Related Organelle Function. PloS Genetics, Oct;9(10):e1003908.
Fischer, SEJ, Q Pan, PC. Breen, Y Qi, Z Shi, C Zhang, TA Montgomery, and G Ruvkun. 2013. Multiple C. elegans silencing pathways converge to silence duplicated sequences Genes and Development, 2013 Dec 15;27(24):2678-95.
Garcia, SMDA, Y Tabach, G Lourenço, and G Ruvkun. 2014. Identification of genes in toxicity pathways of trinucleotide repeat RNA in C. elegans toxicity. Nature Structural and Molecular Biology, 2014 Aug;21(8):712-20.
Liu, Y, PC Breen and G Ruvkun. 2014. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014 Apr 17;508(7496):406-10.
185 Cambridge Street, Boston, MA 02114