Bernardo L. Sabatini
Department of Neurobiology, Harvard Medical School
Investigator, Howard Hughes Medical Institute
The main focus of my research laboratory is to understand the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.
Our studies include analysis of:
The biophysical processes that control the function of individual synapses.
The mechanisms of regulation of synapses and neurons by neuromodulators such as dopamine, acetylcholine, and peptides.
The relationship between synaptic plasticity and behavior.
The role of perturbed synapse function in human neuropsychiatric diseases such as autism, Parkinson’s and Alzheimer’s.
Our studies are performed in the mammalian brain and we focus on the analysis of hippocampus, cortex, and basal ganglia. Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure. Lastly, as necessary for our studies, we develop novel optical, electrophysiological, and behavioral approaches to carry out the proposed work. Greater detail and a complete list of publications can be found at our laboratory web page.
Wallace ML, Saunders A, Huang KW, Philson AC, Goldman M, Macosko EZ, McCarroll SA, Sabatini BL. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017;94 (1) :138-152.
Pisanello F, Mandelbaum G, Pisanello M, Oldenburg IA, Markowitz JE, Peterson RE, Patria DA, Haynes TM, Emara MS, Spagnolo B, et al. Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber. Nature Neuroscience. 2017;20 (8) :1180-1190.
Hou XH, Hyun M, Taranda J, Huang KW, Todd E, Feng D, Atwater E, Croney D, Zeidel ML, Osten P, et al. Central Control Circuit for Context-Dependent Micturition. Cell. 2016;167 (1) :73-86.
Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, et al. A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016;91 (1) :25-33.
Straub C, Saulnier JL, Bègue A, Feng DD, Huang KW, Sabatini BL. Principles of Synaptic Organization of GABAergic Interneurons in the Striatum. Neuron. 2016;92 (1) :84-92.
Peixoto RT, Wang W, Croney DM, Kozorovitskiy Y, Sabatini BL. Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) mice. Nature Neuroscience. 2016;19 (5) :716-724.
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