Metabolic pathways provide essential energy and building blocks for the function of all...
DNA replication and repair mechanisms that suppress genomic instability.
Xenopus laevis egg extracts have an extraordinary capacity to recapitulate key events of cell cycle progression in vitro, including DNA replication and repair, mitosis, and...
We are a computational genetics and genomics lab whose main research is on genetic variation, including mechanisms of spontaneous mutagenesis, functional effects of mutations and allelic variants, population genetics and relationship between genotype and...
Research in the Shih laboratory focuses on design of self-assembling biomolecular machines and their diagnostic and therapeutic applications.
Tools For Molecular Biophysics:
NMR Structure Determination of Membrane Proteins An outstanding problem in...
To arrive at a decision, organisms must measure multiple environmental signals and interpret them appropriately. The questions we are interested in are how cells and organisms interpret...
The Needleman laboratory investigates how the cooperative behaviors of molecules give rise to the architecture and dynamics of self-organizing subcellular structures.
These collective effects are not only directly relevant to cellular organization, they...
We study the neural circuit and molecular basis of individual differences in behavior using custom high-throughput instrumentation, with an eye to its ultimate cause in evolution.
The animal kingdom contains staggering morphological diversity, but even...
The long-term goal of the Brown laboratory is to understand the structure and function of cilia (also known as eukaryotic flagella).
Cilia are finger-like organelles that project from the surface of almost all eukaryotic cells. Motile cilia produce a...