Algorithms and Neural Circuits in Olfaction.
We are interested in understanding the neural and algorithmic basis of odor-guided behaviors in terrestrial animals. To this end, we have developed behavioral tasks in mice using stimuli and situations that...
Our laboratory investigates the molecular mechanisms of the vertebrate immune system.
We are particularly interested in protein aggregates, namely “functional aggregates”, that play increasingly important and common functions in immune systems. Our...
Molecular Principles Enabling Structural Diversification of Very Long-Chain Fatty Acids. The budding yeast S. cerevisiae is a model organism in which the power of genetic screening and genomic analysis can be combined with biochemical reconstitution...
We study the neural circuit and molecular basis of individual differences in behavior using custom high-throughput instrumentation, with an eye to its ultimate cause in evolution.
The animal kingdom contains staggering morphological diversity, but even...
Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering.
Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems –...
Statistical computations and neuronal mechanisms underlying complex decisions and behavior under uncertainty. The work in the lab is theoretical in nature, and we collaborate with experimentalists in a close loop to refine both theories and experiments...
Chromosome Mechanics and Dynamics
We are interested in complex chromosomal behaviors that lack satisfactory explanations. We emphasize new approaches, quantitative analysis and hypotheses that are orthogonal to general dogma. Current work combines...
We use both theory and experiments to study evolutionary dynamics and population genetics, particularly in situations where natural selection is pervasive.
Natural selection and other evolutionary forces lead to particular patterns of evolutionary...
Structural biology of signaling and transport through biological membranes.
My lab is broadly interested in the mechanisms of signaling and transport across cellular membranes. We use a variety of cell-based and in vitro biochemical assays, x-ray...