Our lab studies microbial evolution, primarily of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance.
This will require advances both in technology and in the basic science of resistance evolution...
DNA replication and repair mechanisms that suppress genomic instability.
Xenopus laevis egg extracts have an extraordinary capacity to recapitulate key events of cell cycle progression in vitro, including DNA replication and repair, mitosis, and...
We are a computational genetics and genomics lab whose main research is on genetic variation, including mechanisms of spontaneous mutagenesis, functional effects of mutations and allelic variants, population genetics and relationship between genotype and...
The Silver Lab seeks to enhance our understanding of natural biological design, and to develop tools and concepts for designing cells, tissues and organisms.
What can we build with biology? We use a synthetic biology approach to understanding biological...
Multiscale Theoretical and Experimental Studies of Physical Chemical Principles of Living Matter.
Mutations increase genetic diversity and affect molecular properties of proteins (stability, activity, solubility,etc.), while natural selection is the...
To arrive at a decision, organisms must measure multiple environmental signals and interpret them appropriately. The questions we are interested in are how cells and organisms interpret...
The Prentiss group focuses on using physics tools to elucidate important problems in biology. The basic principles governing self-assembly have been a focus of recent work.
It has long been known that any complex self-assembling system faces a...
The Needleman laboratory investigates how the cooperative behaviors of molecules give rise to the architecture and dynamics of self-organizing subcellular structures.
These collective effects are not only directly relevant to cellular organization, they...
We are interested in understanding how epigenetic chromatin domains are assembled and stably propagated.
Research in the Moazed lab is focused on the remarkable ability of heterochromatic domains of DNA to heritably silence genes and transposons. These...