The Needleman laboratory investigates how the cooperative behaviors of molecules give rise to the architecture and dynamics of self-organizing subcellular structures.
These collective effects are not only directly relevant to cellular organization, they...
We are interested in understanding how epigenetic chromatin domains are assembled and stably propagated.
Research in the Moazed lab is focused on the remarkable ability of heterochromatic domains of DNA to heritably silence genes and transposons. These...
Algorithms and Neural Circuits in Olfaction.
We are interested in understanding the neural and algorithmic basis of odor-guided behaviors in terrestrial animals. To this end, we have developed behavioral tasks in mice using stimuli and situations that...
DNA-TEMPLATED SMALL MOLECULES The discovery, synthesis, delivery and testing of small bioactive molecules remains an active focus of chemists in both...
Cerebrospinal Fluid-based Signaling During Brain Development and in Disease.
Defined numbers of neural precursor cells are remarkably synchronized in their task to form the brain, yet no central command coordinating this process has been identified...
Our research focuses on the processes that mediate and regulate the movement of...
Research in the Kruse Lab centers on molecular mechanisms of signal transduction by transmembrane receptors.
Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying...
Chromosome Mechanics and Dynamics
We are interested in complex chromosomal behaviors that lack satisfactory explanations. We emphasize new approaches, quantitative analysis and hypotheses that are orthogonal to general dogma. Current work combines...
The Loparo laboratory is focused on using biochemical and biophysical tools to study the mechanisms of genome maintenance with molecular resolution.
My laboratory is focused on developing and applying single-molecule methods to understand the dynamics...
Using computational tools, modeling, and analysis of genomic data to address fundamental problems in biological physics and evolution.
Our laboratory research focuses on two major projects:
* Understanding 3D genome organization by computer modeling and...