Our lab studies microbial evolution, primarily of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance.
This will require advances both in technology and in the basic science of resistance evolution...
We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed at treating or preventing infection.
Several enveloped RNA viruses cause human viral hemorrhagic fevers...
We seek to understand fundamental signaling mechanisms and principles by dissecting out and determining the structure of “regulatory modules” –...
Molecular Principles Enabling Structural Diversification of Very Long-Chain Fatty Acids. The budding yeast S. cerevisiae is a model organism in which the power of genetic screening and genomic analysis can be combined with biochemical reconstitution...
We study the neural circuit and molecular basis of individual differences in behavior using custom high-throughput instrumentation, with an eye to its ultimate cause in evolution.
The animal kingdom contains staggering morphological diversity, but even...
The long-term goal of the Brown laboratory is to understand the structure and function of cilia (also known as eukaryotic flagella).
Cilia are finger-like organelles that project from the surface of almost all eukaryotic cells. Motile cilia produce a...Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering.
Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems –...
Researching Alzheimer's disease using multiphoton microscopy to observe, in vivo, the anatomy and physiology of specific cell type in the brain.Our laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease...