Understanding how the brain controls behavior by integrating external sensory information with internal states, such as attention or motivation.
In our lab in the Department of Neurobiology at Harvard Medical School, we worked for many years with non...
Therapeutic Targeting of Protein-Protein Interactions. Protein-Protein Interactions (PPIs) are the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab...
Statistical computations and neuronal mechanisms underlying complex decisions and behavior under uncertainty. The work in the lab is theoretical in nature, and we collaborate with experimentalists in a close loop to refine both theories and experiments...
We use both theory and experiments to study evolutionary dynamics and population genetics, particularly in situations where natural selection is pervasive.
Natural selection and other evolutionary forces lead to particular patterns of evolutionary...
The Blacklow laboratory studies biochemical and molecular mechanisms of signal transduction. A major focus is on elucidating key events mediated by the Notch signaling pathway in health and disease.
The primary long-term goal of our research program is...
The goal of my lab is to understand the role of corticolimbic areas in guiding attention to, and imagery, learning and memory of, motivationally-salient external and interoceptive stimuli.
The way that external stimuli are encoded in brain activity is...
Neural circuits and behavior in larval zebrafish
The general goal of the laboratory is the comprehensive identification and examination of neural circuits controlling behavior using the larval zebrafish as a model system. To that end, we have established...
Bacterial toxin biology, therapeutics, and mechanism of membrane trafficking
Our laboratory has a broad interest in microbial toxins, bacterial pathogenesis in human/animal/insects, and microbiome. Along these lines of basic research, we are keen in...
Physical tools to study molecules, cells, and organisms.
We invent new physical tools to probe biological structures. We use our tools to make new measurements. We choose problems by looking in unexplored regimes of time and space. We combine protein...
Our quest is an understanding of the behavior of bacteria at the molecular level, especially behavior involving chemical stimuli (chemotaxis)
Flagellated bacteria possess a remarkable motility system based on a reversible rotary motor linked by a...