My laboratory is interested in the role of spatial organization in host-microbe interactions in the mammalian gut. We develop, extend, and utilize image-based approaches to spatial genomics, including a massively multiplexed single-molecule RNA imaging...
Algorithms and Neural Circuits in Olfaction.
We are interested in understanding the neural and algorithmic basis of odor-guided behaviors in terrestrial animals. To this end, we have developed behavioral tasks in mice using stimuli and situations that...
We are interested in understanding how epigenetic chromatin domains are assembled and stably propagated.
Research in the Moazed lab is focused on the remarkable ability of heterochromatic domains of DNA to heritably silence genes and transposons. These...
Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering.
Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems –...
Our DNA represents the full...
My lab designs new protein tools, artificial enzymes, and biomedicines to sense and re-direct cell signaling responses.
Molecular recognitions, such as receptor-ligand binding, enzyme-substrate recognition, or metabolite-protein interaction, are...
The Silver Lab seeks to enhance our understanding of natural biological design, and to develop tools and concepts for designing cells, tissues and organisms.
What can we build with biology? We use a synthetic biology approach to understanding biological...
To arrive at a decision, organisms must measure multiple environmental signals and interpret them appropriately. The questions we are interested in are how cells and organisms interpret...
Our lab studies microbial evolution, primarily of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance.
This will require advances both in technology and in the basic science of resistance evolution...
Chromosome Mechanics and Dynamics
We are interested in complex chromosomal behaviors that lack satisfactory explanations. We emphasize new approaches, quantitative analysis and hypotheses that are orthogonal to general dogma. Current work combines...
Our laboratory investigates the molecular mechanisms of the vertebrate immune system.
We are particularly interested in protein aggregates, namely “functional aggregates”, that play increasingly important and common functions in immune systems. Our...