Cellular Biophysics

Algorithms and Neural Circuits in Olfaction.

We are interested in understanding the neural and algorithmic basis of odor-guided behaviors in terrestrial animals. To this end, we have developed behavioral tasks in mice using stimuli and situations that...

Next-Generation Macromolecular and Small-Molecule Tools for the Understanding and Treatment of Disease.

DNA-TEMPLATED SMALL MOLECULES The discovery, synthesis, delivery and testing of small bioactive molecules remains an active focus of chemists in both...

Our objective is to bridge the gap between molecules and cells, either as independent entities in culture, as components of organoids, or as components of living tissues.

Our research focuses on the processes that mediate and regulate the movement of...

The central aim of my current research is to understand the mechanical basis of protein function, that is, the collective motions and the forces that guide these motions, enabling the conformational and energetic changes required for functional...

The overall objective of our research is to understand how protein interactions determine subcellular structure. We use direct structural approaches – principally X-ray crystallography, often in combination with electron microscopy – to determine the...

Using in vivo dynamics of single molecules to dissect the mechanisms controlling bacterial shape and growth.

 

My group works to understand how cells create long range order: How enzymes, each acting at the nanometer scale, work together to build micron...

Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering.

Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems –...

Chromosome Mechanics and Dynamics

 

We are interested in complex chromosomal behaviors that lack satisfactory explanations.  We emphasize new approaches, quantitative analysis and hypotheses that are orthogonal to general dogma.   Current work combines...

The Loparo laboratory is focused on using biochemical and biophysical tools to study the mechanisms of genome maintenance with molecular resolution.

My laboratory is focused on developing and applying single-molecule methods to understand the dynamics...

Members of the Zhuang laboratory apply their diverse backgrounds in physics,  chemistry, biology, and engineering to develop advanced imaging methods and to exploit these tools to study a variety of interesting biological problems.  Understanding the...