The Farnung Lab is interested in molecular mechanisms at the interface of transcription and chromatin.
We employ biochemical, biophysical, machine learning, and structural biology approaches to understand how the transcription machinery, histone...
My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis.
We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of...
Our research studies the molecular mechanisms of cellular fatty acid metabolism and lipid recycling pathways.
A long-term goal of my laboratory is to address mechanisms of cellular fatty acid metabolism and their implication in neuronal functions. Fatty...
My research program focuses on studying specialized translation mechanisms in parasites that significantly burden global health, including, but not limited to, Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing...
Our lab seeks to enable the dissection of tissues into the rules which govern their organization.
Genomic tools for understanding tissue function are critically needed. Applying genomic technologies to tissues has faced three major challenges: first, to...
Our lab studies protein design and molecular recognition.
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens...
Projects in our lab focus on mechanotransduction or the conversion of mechanical signals into electrical signals in the inner ear. The process underlies our senses of hearing and balance. We have identified several proteins critical for...
My lab designs new protein tools, artificial enzymes, and biomedicines to sense and re-direct cell signaling responses.
Molecular recognitions, such as receptor-ligand binding, enzyme-substrate recognition, or metabolite-protein interaction, are...
Our lab studies the molecular mechanisms of sensory transduction, seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals. In particular, we focus on the sense of smell in...
Our DNA represents the full...