Our lab focuses on the development of adaptive immune responses, protein evolution, and the
interactions between host and pathogen using a combination of biophysical, biochemical, and
molecular virology techniques.
We are primarily protein engineers and...
We develop and apply single molecule approaches to acquire quantitative understanding of biology and to find ways to improve human medicine.
The current directions of our research include investigations of G-quadruplex and R-loop mediated gene...
Therapeutic Targeting of Protein-Protein Interactions. Protein-Protein Interactions (PPIs) are the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab...
My research program focuses on studying specialized translation mechanisms in parasites that significantly burden global health, including, but not limited to, Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing...
The Farnung Lab is interested in molecular mechanisms at the interface of transcription and chromatin.
We employ biochemical, biophysical, machine learning, and structural biology approaches to understand how the transcription machinery, histone...
Our lab studies protein design and molecular recognition.
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens...
My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis.
We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of...
Our research group applies Positron Emission Tomography (PET), molecular imaging principles, and pharmacokinetic modeling methods to measure physiological parameters in vivo to better understand healthy brain function, aging, neuropsychiatric disorders...
My research seeks to uncover the principles that govern how neural circuits, both biological and artificial, represent and transform information.
A central focus of my group is the geometry of neural population activity, or “neural manifolds,” which...
The overall objective of our research is to understand how protein interactions determine subcellular structure. We use direct structural approaches – principally X-ray crystallography, often in combination with electron microscopy – to determine the...
The overarching goal of my lab is to develop novel statistical methods that combine theory and computation to extract useful information from biological information and provide tools for the whole research community.
One million human genomes, will it...