Structural Biology

We develop fluorescent biosensors for metabolism, and use quantitative two-photon imaging to learn about the regulation and dynamics of cellular metabolism in brain.

Metabolic pathways provide essential energy and building blocks for the function of all...

DNA replication and repair mechanisms that suppress genomic instability.

Xenopus laevis egg extracts have an extraordinary capacity to recapitulate key events of cell cycle progression in vitro, including DNA replication and repair, mitosis, and...

We study receptor-ligand interactions and transmembrane signal transmission that are relevant to immunology, hemostasis, and human disease using structural, cell biological, and single molecule techniques.

We work on receptor-ligand interactions and...

Research in the Shih laboratory focuses on design of self-assembling biomolecular machines and their diagnostic and therapeutic applications.

Tools For Molecular Biophysics:

NMR Structure Determination of Membrane Proteins An outstanding problem in...

Multiscale Theoretical and Experimental Studies of Physical Chemical Principles of Living Matter.

Mutations increase genetic diversity and affect molecular properties of proteins (stability, activity, solubility,etc.), while natural selection is the...

We are interested in understanding how epigenetic chromatin domains are assembled and stably propagated.

Research in the Moazed lab is focused on the remarkable ability of heterochromatic domains of DNA to heritably silence genes and transposons. These...

We study cell signaling and regulation of the actin cytoskeleton using structural and biochemical approaches.

We seek to understand fundamental signaling mechanisms and principles by dissecting out and determining the structure of “regulatory modules” –...

We aim to understand the molecular mechanisms that determine the fate of new proteins using in vitro reconstitution, cell biology, and structural biology approaches.   Protein biosynthesis is a complex process encompassing translation, protein folding...

Our laboratory investigates the molecular mechanisms of the vertebrate immune system.

We are particularly interested in protein aggregates, namely “functional aggregates”, that play increasingly important and common functions in immune systems. Our...

The central aim of my current research is to understand the mechanical basis of protein function, that is, the collective motions and the forces that guide these motions, enabling the conformational and energetic changes required for functional...