Faculty U-Z

My lab designs new protein tools, artificial enzymes, and biomedicines to sense and re-direct cell signaling responses.

Molecular recognitions, such as receptor-ligand binding, enzyme-substrate recognition, or metabolite-protein interaction, are...

Studying RNA chemical modifications that are guided by imprinted non-coding and how differences in the three-dimensional folding of the two parental genomes in offspring impacts imprinted expression and neurodevelopment.

Our DNA represents the full...

My research centers on the development and application of novel medical imaging techniques (mainly MRI) for the clinical and scientific investigation of the brain diseases and function.The goal is often to increase the sensitivity, scope and utility of...

Foundation of Information Directed Molecular Technology: Programming Nucleic Acid Self-Assembly.  

My research interests lie at the interface of information science, molecular engineering, and biology.  We are interested in engineering digitally...

We develop fluorescent biosensors for metabolism, and use quantitative two-photon imaging to learn about the regulation and dynamics of cellular metabolism in brain.

Metabolic pathways provide essential energy and building blocks for the function of all...

We investigate how force regulates the structure and dynamics of interactions between and within single-molecules, and how this in turn can affect the functioning and malfunctioning of biological systems.  Our group is interested in understanding the...

DNA replication and repair mechanisms that suppress genomic instability.

Xenopus laevis egg extracts have an extraordinary capacity to recapitulate key events of cell cycle progression in vitro, including DNA replication and repair, mitosis, and...

Members of the Zhuang laboratory apply their diverse backgrounds in physics,  chemistry, biology, and engineering to develop advanced imaging methods and to exploit these tools to study a variety of interesting biological problems.  Understanding the...

Our research is focused on protein structure, dynamics and stability, and on the relation of these to protein function using NMR and computational techniques as the main tools used to address these problems.We are interested in improving NMR methods and...

The Wu laboratory of mechanistic immunology focuses on elucidating cellular and structural regulation in innate immune pathways, in particular the inflammasome pathway.

Research Interests:

The Wu laboratory of structural immunology focuses on elucidating...