Our research explores how we learn from our mistakes. As infants learning to walk, we take unsteady steps, fall, adjust, and eventually develop stable locomotion. This iterative cycle of action, error, and refinement continues throughout life, shaping our...
The Farnung Lab is interested in molecular mechanisms at the interface of transcription and chromatin.
We employ biochemical, biophysical, machine learning, and structural biology approaches to understand how the transcription machinery, histone...
Our lab studies microbial evolution, primarily of antibiotic resistance, with a goal of developing practical interventions to reduce or reverse resistance.
This will require advances both in technology and in the basic science of resistance evolution...
We are interested in understanding how epigenetic chromatin domains are assembled and stably propagated.
Research in the Moazed lab is focused on the remarkable ability of heterochromatic domains of DNA to heritably silence genes and transposons. These...
Cerebrospinal Fluid-based Signaling During Brain Development and in Disease.
Defined numbers of neural precursor cells are remarkably synchronized in their task to form the brain, yet no central command coordinating this process has been identified...
We aim to understand the molecular mechanisms that determine the fate of new proteins using in vitro reconstitution, cell biology, and structural biology approaches. Protein biosynthesis is a complex process encompassing translation, protein folding...
My research interests lie at the interface of information science, molecular engineering, and biology. We are interested in engineering digitally...
The Silver Lab seeks to enhance our understanding of natural biological design, and to develop tools and concepts for designing cells, tissues and organisms.
What can we build with biology? We use a synthetic biology approach to understanding biological...
My laboratory is interested in the role of spatial organization in host-microbe interactions in the mammalian gut. We develop, extend, and utilize image-based approaches to spatial genomics, including a massively multiplexed single-molecule RNA imaging...
The Blacklow laboratory studies biochemical and molecular mechanisms of signal transduction. A major focus is on elucidating key events mediated by the Notch signaling pathway in health and disease.
The primary long-term goal of our research program is...
My group works to understand how cells create long range order: How enzymes, each acting at the nanometer scale, work together to build micron...