Seon S. Kinrot

Dissertation Title:  Exploring Single-Cell Chromatin Organization with Multiplexed DNA-FISH: Towards an Imaging Platform for Single-Cell Multi-Omics

PhD Dissertation Advisor: Dr. Xiaowei Zhuang, Dept. of Chemistry and Chemical Biology

I have been interesting in a range of topics, of which some of the major ones were imaging and optics, equilibrium and non-equilibrium statistical mechanics, statistical and stochastic effects in biology, single-molecule biophysics and gene expression and regulation. My background is in both Physics and Biology (I did a double major in undergrad) and I enjoy looking for physical explanations to biological phenomena.  My research in the Zhuang laboratory focused on investigating the hgher order structure of chromatin and its relation to regulation of gene expression, mainly using imaging techniques.

Since graduating, I transitioned to working full-time on the dry-lab/ analysis side.

I spent a couple of years leading the computational and data analysis work in a biotech startup called RootPath. The company had developed a proprietary technology to synthetically generate custom pools of full-length genes and other long DNA sequences, and was focused on applying this technology to create individualized T-cell treatments for cancer patients.

Since the end of 2023, I've been working as a research scientist in the Center for Disease Neurogenomics at Mount Sinai. The group is generally focused on understanding the molecular mechanisms underlying neuropsychiatric disease, through the lens of genetics and gene expression. I am involved in a range of projects in the group, largely with a focus on method development and/ or analysis of spatial transcriptomics data.