# George M. Church, Ph.D. (He/ Him/ His) Robert Winthrop Professor of Genetics, & Health Sciences & Technology, Harvard Medical School/ MIT Director of HMS NHGRI-Center of Excellence in Genomic Science, Director of Personal Genome Project Broad Institute & Wyss Harvard Institute of Biologically Inspired Engineering ![GeorgeChurchPhoto](/sites/g/files/omnuum9451/files/styles/hwp_4_5__320x400/public/biophysics/files/george_church_headshot.jpg?itok=k_9PfSS4) location\_on Harvard Medical School Department of Genetics New Research Building, Room 238 77 Avenue Louis Pasteur Boston, MA 02115 smartphone [617 432-1278]() email [church\_lab\_admin@hms.harvard.edu](mailto:church_lab_admin@hms.harvard.edu) laptop\_windows [Church Laboratory Home Page](http://arep.med.harvard.edu) laptop\_windows [Church Laboratory Complete Publications List](http://arep.med.harvard.edu/gmc_pub.html) Pursuing "Next generation" DNA sequencing methods and chip-DNA-synthesis, gene editing and stem cell engineering. Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems – in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses. **Current Lab Members:** 15 Graduate Students 40 Postdoctoral Fellows **Selected Publications:** Dantas, G., Sommer, M.O., Oluwasegun, R.D., and Church, G.M. (2008) Bacteria Subsisting on Antibiotics. *Science* 320(5872):100-3. Bang, D., and Church, G.M. (2008) Gene Synthesis by Circular Assembly Amplification. *Nature Methods* 5(1):37-9. Kim, J.B., Porreca, G.J., Gorham, J.M., Church, G.M., Seidman, C.E., and Seidman, J.G. (2007) Polony Multiplex Analysis of Gene Expression (PMAGE) in a Mouse Model of Hypertrophic Cardiomyopathy. *Science* 316(5830):1481-4. Bakal, C., Aach, J., Church, G.M., and Perrimon, N. (2007) Defining the Components Of Local Signaling Networks That Regulate Cell Morphology Using Quantitative Morphological Signatures. *Science* 316(5832):1753-6. Profile Photograph Credit: Wyss Institute at Harvard University - ## Faculty Alphabetical [Faculty A-E](/people-alphabetical/e) - ## People Terms [Faculty](/people-terms/faculty) [Core/ Training Grant Faculty](/people-terms/core-faculty) [Accepting Rotation Students](/people-terms/accepting-rotation-students) [Cellular Biophysics](/people-terms/cellular-imaging) [Genetics/ Genomics, Proteomics & Transcriptomics](/people-terms/genomics) [Methods Development](/people-terms/tech-development) [Theoretical & Computational Biology](/people-terms/computational-biology-bioinformatics)